Pigeon Mitogen Activated Protein Kinase Kinase Kinase Kinase 3 (MAP4K3) ELISA Kit | MAP4K3 elisa kit
Pigeon Mitogen Activated Protein Kinase Kinase Kinase Kinase 3 (MAP4K3) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
a mitogen-activated protein kinase kinase kinase kinase that functions upstream of c-Jun N-terminal kinase [RGD, Feb 2006]
Uniprot Description
KHS2: an ubiquitous protein kinase of the STE20 family. May play a role in the response to environmental stress. Regulated by amino acids and acts upstream of mTORC1 and JNK. Required for maximal S6K and 4E-BP1 phosphorylation. Interacts with PPP2R5E, a regulatory subunit of PP2A. Following amino acid withdrawal, pS170 is dephosphorylated via PP2A. The dephosphorylation of pS170 by PP2A in response to amino acid restriction inhibits mTORC1 signaling. The inhibition of PPP2R5E expression prevents the dephosphorylation of KHS2 pS170, impairing mTORC1 inhibition during amino acid withdrawal. Three alternatively spliced isoforms have been described.
Protein type: EC 2.7.11.1; KHS subfamily; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family
Chromosomal Location of Human Ortholog: 6q11
Cellular Component: cytoplasm; intracellular
Molecular Function: ATP binding; MAP kinase kinase kinase kinase activity; protein serine/threonine kinase activity
Biological Process: activation of MAPKKK activity; MAPK cascade; protein amino acid phosphorylation; regulation of apoptosis; regulation of mitotic cell cycle; response to tumor necrosis factor; response to UV; stress-activated protein kinase signaling pathway
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Product Notes
The Pigeon MAP4K3 map4k3 (Catalog #AAA9397891) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9397891 ELISA Kit recognizes Pigeon MAP4K3. It is sometimes possible for the material contained within the vial of "Mitogen Activated Protein Kinase Kinase Kinase Kinase 3 (MAP4K3), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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