Plant E3 Ubiquitin-Protein Ligase SIAH2 (SIAH2) ELISA Kit | SIAH2 elisa kit
Plant E3 Ubiquitin-Protein Ligase SIAH2 (SIAH2) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia. [provided by RefSeq, Jul 2008]
Uniprot Description
SIAH2: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 can not. Promotes monoubiquitination of SNCA. Homodimer. Interacts with UBE2E2. Interacts with PEG3. Interacts with VAV1, without mediating its ubiquitin- mediated degradation. Interacts with CACYBP/SIP. Probable component of some large E3 complex possibly composed of UBE2D1, SIAH2, CACYBP/SIP, SKP1, APC and TBL1X. Interacts with PEG10, which may inhibit its activity. Interacts with EGLN2 and SNCAIP. Widely expressed at low level. Inhibited by interaction with SNCAIP (isoform 2, but not isoform 1). May be inhibited by interaction with PEG10. Belongs to the SINA (Seven in absentia) family.
Protein type: Transcription, coactivator/corepressor; Ubiquitin ligase; EC 6.3.2.19; Ubiquitin conjugating system; Ligase; EC 6.3.2.-
Chromosomal Location of Human Ortholog: 3q25
Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; nucleoplasm; nucleus
Molecular Function: protein binding; transcription corepressor activity; ubiquitin-protein ligase activity
Biological Process: axon guidance; cellular protein catabolic process; cellular protein metabolic process; negative regulation of apoptosis; negative regulation of caspase activity; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; small GTPase mediated signal transduction; ubiquitin-dependent protein catabolic process
Research Articles on SIAH2
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Product Notes
The Plant SIAH2 siah2 (Catalog #AAA9381851) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9381851 ELISA Kit recognizes Plant SIAH2. It is sometimes possible for the material contained within the vial of "E3 Ubiquitin-Protein Ligase SIAH2 (SIAH2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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