Pigeon Homeobox A11 (HOXA11) ELISA Kit | HOXA11 elisa kit

Pigeon Homeobox A11 (HOXA11) ELISA Kit

• Gene Names: HOXA11; HOX1; HOX1I; RUSAT1
• Reactivity: Pigeon
• Synonyms: Homeobox A11 (HOXA11); Pigeon Homeobox A11 (HOXA11) ELISA Kit; HOXA11 elisa kit

• Reactivity: Pigeon
• Sequence Length: 313

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 26454733
• NCBI GeneID: 3207
• Molecular Weight: 34,486 Da
• NCBI Official Full Name: Homeobox A11
• NCBI Official Synonym Full Names: homeobox A11
• NCBI Official Symbol: HOXA11
• NCBI Official Synonym Symbols: HOX1; HOX1I; RUSAT1
• NCBI Protein Information: homeobox protein Hox-A11
• UniProt Protein Name: Homeobox protein Hox-A11
• Protein Family: Homeobox protein
• UniProt Gene Name: HOXA11
• UniProt Synonym Gene Names: HOX1I
• UniProt Entry Name: HXA11_HUMAN

NCBI Description

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. [provided by RefSeq, Jul 2008]

Uniprot Description

HOXA11: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Defects in HOXA11 are the cause of radioulnar synostosis with amegakaryocytic thrombocytopenia (RSAT). The syndrome consists of an unusual association of bone marrow failure and skeletal defects. Patients have the same skeletal defects, the proximal fusion of the radius and ulna, resulting in extremely limited pronation and supination of the forearm. Some patients have also symptomatic thrombocytopenia, with bruising and bleeding problems since birth, necessitating correction by bone marrow or umbilical-cord stem-cell transplantation. Belongs to the Abd-B homeobox family.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 7p15.2

Cellular Component: protein complex; transcription factor complex

Biological Process: anatomical structure morphogenesis; developmental growth; dorsal/ventral pattern formation; embryonic limb morphogenesis; mesodermal cell fate specification; multicellular organismal development; positive regulation of chondrocyte differentiation; positive regulation of transcription, DNA-dependent; skeletal development; ureteric bud branching

Disease: Radioulnar Synostosis With Amegakaryocytic Thrombocytopenia