Pigeon High Mobility Group Protein 1 (HMG1) ELISA Kit | HMG1 elisa kit

Pigeon High Mobility Group Protein 1 (HMG1) ELISA Kit

• Gene Names: HMGB1; HMG1; HMG-1
• Reactivity: Pigeon
• Synonyms: High Mobility Group Protein 1 (HMG1); Pigeon High Mobility Group Protein 1 (HMG1) ELISA Kit; HMG1 elisa kit

• Reactivity: Pigeon

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 45382473
• NCBI GeneID: 395724
• NCBI Accession #: NP_990233.1
• NCBI GenBank Nucleotide #: NM_204902.2
• Molecular Weight: 24,909 Da
• NCBI Official Full Name: high mobility group protein B1
• NCBI Official Synonym Full Names: high mobility group box 1
• NCBI Official Symbol: HMGB1
• NCBI Official Synonym Symbols: HMG1; HMG-1
• NCBI Protein Information: high mobility group protein B1
• UniProt Protein Name: High mobility group protein B1
• Protein Family: High mobility group protein
• UniProt Gene Name: HMGB1
• UniProt Synonym Gene Names: HMG1; HMG-1
• UniProt Entry Name: HMGB1_CHICK

Uniprot Description

Multifunctional redox sensitive protein with various roles in different cellular compartments. Nuclear functions are attributed to fully reduced HGMB1. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA, DNA-containing cruciforms or bent structures, supercoiled DNA and ZDNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Can restructure the canonical nucleosome. Proposed to be an universal biosensor for nucleic acids. May promote inflammatory response to sterile and infectious signals and may be involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm may function as sensor and/or chaperone for immunogenic nucleic acids, and mediate autophagy. May act as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury.