Mouse suppressor of variegation 3-9 homolog 2 (Drosophila) ELISA Kit | SUV39H2 elisa kit
Mouse Histone-lysine N-methyltransferase SUV39H2, SUV39H2 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
SUV39H2: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Methyltransferase, protein lysine; Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase
Cellular Component: nuclear heterochromatin; chromosome; chromatin; nucleus; chromosome, pericentric region
Molecular Function: transferase activity; methyltransferase activity; protein binding; zinc ion binding; metal ion binding; histone lysine N-methyltransferase activity (H3-K9 specific); chromatin binding; protein methyltransferase activity; histone-lysine N-methyltransferase activity
Biological Process: methylation; transcription, DNA-dependent; rhythmic process; negative regulation of transcription from RNA polymerase II promoter; chromatin modification; cell cycle; peptidyl-lysine methylation; chromatin assembly or disassembly; chromatin remodeling; regulation of transcription, DNA-dependent; negative regulation of circadian rhythm; cell differentiation; negative regulation of transcription, DNA-dependent; histone H3-K9 methylation
Research Articles on SUV39H2
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Product Notes
The Mouse SUV39H2 suv39h2 (Catalog #AAA9343045) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9343045 ELISA Kit recognizes Mouse SUV39H2. It is sometimes possible for the material contained within the vial of "suppressor of variegation 3-9 homolog 2 (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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