Human core-binding factor, runt domain, alpha subunit 2; translocated to, 3 ELISA Kit | CBFA2T3 elisa kit
Human Protein CBFA2T3, CBFA2T3 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
Uniprot Description
CBFA2T3: a transcriptional repressor encoded by a gene on chromosome arm 16q, the second most frequent target of loss of heterozygosity in breast cancer. May have tumour suppressor activity. Interacts with ZNF652, a novel zinc finger protein, to repress transcription.
Protein type: Transcription, coactivator/corepressor; Nucleolus
Chromosomal Location of Human Ortholog: 16q24
Cellular Component: Golgi membrane; nucleoplasm; nucleolus; nucleus
Molecular Function: protein binding; metal ion binding; chromatin binding; transcription corepressor activity; transcription factor activity
Biological Process: cell proliferation; transcription, DNA-dependent; granulocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
Research Articles on CBFA2T3
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Product Notes
The Human CBFA2T3 cbfa2t3 (Catalog #AAA9342893) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9342893 ELISA Kit recognizes Human CBFA2T3. It is sometimes possible for the material contained within the vial of "core-binding factor, runt domain, alpha subunit 2; translocated to, 3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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