Rat tripartite motif-containing 28 ELISA Kit | TRIM28 elisa kit
Rat Transcription intermediary factor 1-beta, TRIM28 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
mouse homolog is a transcriptional repressor; interacts with the Kruppel-associated box A (KRAB-A) domain of C2H2 zinc finger proteins [RGD, Feb 2006]
Uniprot Description
TIF1B: an atypical protein kinase that functions as a transcriptional coactivator. Mediates transcriptional regulation by interaction with the Kruppel-associated box (KRAB) repression domain found in many transcription factors. Binds to the negative regulatory domain of c-Myb and negatively regulates the c-Myb-dependent trans-activation. Localizes to the nucleus and is thought to associate with specific chromatin regions. Phosphorylated in an ATM-dependent manner following double-strand breaks. Its phosphorylation in response to DNA damage leads to chromatin relaxation. A member of the tripartite motif family. The tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.
Protein type: Ubiquitin ligase; Kinase, protein; Ubiquitin conjugating system; Protein kinase, atypical; EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Ligase; ATYPICAL group; TIF1 family
Cellular Component: nucleoplasm; nucleolus; nuclear heterochromatin; chromatin; nucleus
Molecular Function: DNA binding; zinc ion binding; sequence-specific DNA binding; ubiquitin protein ligase binding; transcription coactivator activity; ubiquitin-protein ligase activity; transcription factor activity; transcription corepressor activity; ligase activity; protein kinase activity
Biological Process: convergent extension involved in axis elongation; positive regulation of DNA repair; transcription, DNA-dependent; in utero embryonic development; positive regulation of transcription, DNA-dependent; protein amino acid autophosphorylation; protein ubiquitination; negative regulation of transcription from RNA polymerase II promoter; DNA repair; protein amino acid phosphorylation; protein oligomerization; protein sumoylation; positive regulation of transcription factor import into nucleus; epithelial to mesenchymal transition; innate immune response; DNA methylation during embryonic development; negative regulation of transcription, DNA-dependent; embryo implantation
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Product Notes
The Rat TRIM28 trim28 (Catalog #AAA9342730) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9342730 ELISA Kit recognizes Rat TRIM28. It is sometimes possible for the material contained within the vial of "tripartite motif-containing 28, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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