Human farnesyltransferase, CAAX box, alpha ELISA Kit | FNTA elisa kit
Human Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, FNTA ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, May 2010]
Uniprot Description
FNTA: Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK. Belongs to the protein prenyltransferase subunit alpha family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.5.1.59; Transferase; EC 2.5.1.58
Chromosomal Location of Human Ortholog: 8p11
Cellular Component: microtubule associated complex; cytoplasm; cytosol
Molecular Function: protein binding; protein geranylgeranyltransferase activity; CAAX-protein geranylgeranyltransferase activity; microtubule binding; acetylcholine receptor regulator activity; receptor tyrosine kinase binding; alpha-tubulin binding; protein farnesyltransferase activity; Rab-protein geranylgeranyltransferase activity
Biological Process: rhodopsin mediated signaling; protein geranylgeranylation; phototransduction, visible light; protein farnesylation; regulation of rhodopsin mediated signaling; neurotransmitter receptor metabolic process; apoptosis; transforming growth factor beta receptor signaling pathway; regulation of receptor activity; cell structure disassembly during apoptosis
Research Articles on FNTA
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Product Notes
The Human FNTA fnta (Catalog #AAA9339744) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9339744 ELISA Kit recognizes Human FNTA. It is sometimes possible for the material contained within the vial of "farnesyltransferase, CAAX box, alpha, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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