Human ubiquitin specific peptidase 18 ELISA Kit | USP18 elisa kit
Human Ubl carboxyl-terminal hydrolase 18, USP18 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011]
Uniprot Description
USP18: Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms. Belongs to the peptidase C19 family.
Protein type: Ubiquitin-specific protease; Protease; EC 3.4.19.-; EC 3.1.2.-
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component: nucleus; cytosol
Molecular Function: protein binding; ISG15-specific protease activity; cysteine-type endopeptidase activity; ubiquitin-specific protease activity
Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; cytokine and chemokine mediated signaling pathway
Research Articles on USP18
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Product Notes
The Human USP18 usp18 (Catalog #AAA9338610) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9338610 ELISA Kit recognizes Human USP18. It is sometimes possible for the material contained within the vial of "ubiquitin specific peptidase 18, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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