Human feline leukemia virus subgroup C cellular receptor family, member 2 ELISA Kit | FLVCR2 elisa kit
Human Feline leukemia virus subgroup C receptor-related protein 2, FLVCR2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the major facilitator superfamily. The encoded transmembrane protein is a calcium transporter. Unlike the related protein feline leukemia virus subgroup C receptor 1, the protein encoded by this locus does not bind to feline leukemia virus subgroup C envelope protein. The encoded protein may play a role in development of brain vascular endothelial cells, as mutations at this locus have been associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Aug 2010]
Uniprot Description
FLVCR2: Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism. Defects in FLVCR2 are the cause of proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH). It is a rare prenatally lethal disorder characterized by hydranencephaly, a distinctive glomerular vasculopathy in the central nervous system and retina, and diffuse ischemic lesions of the brain stem, basal ganglia, and spinal cord with calcifications. Hydranencephaly is a condition where the greater portions of the cerebral hemispheres and corpus striatum are replaced by cerebrospinal fluid and glial tissue. Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 14q24.3
Cellular Component: integral to membrane; plasma membrane
Molecular Function: heme transporter activity; heme binding
Biological Process: heme transport; transmembrane transport
Disease: Proliferative Vasculopathy And Hydranencephaly-hydrocephaly Syndrome
Research Articles on FLVCR2
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Product Notes
The Human FLVCR2 flvcr2 (Catalog #AAA9338550) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9338550 ELISA Kit recognizes Human FLVCR2. It is sometimes possible for the material contained within the vial of "feline leukemia virus subgroup C cellular receptor family, member 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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