Human tripartite motif-containing 24 ELISA Kit | TRIM24 elisa kit
Human Transcription intermediary factor 1-alpha, TRIM24 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
TRIM24: an atypical protein kinase that functions as a transcriptional coactivator. Originally identified as a mammalian protein that enhances the AF-2 activity of the retinoid X receptor (RXR) in a yeast genetic screen. Binds to nuclear receptors in an agonist and AF2-activating domain (AF2-AD) dependent manner. Binding to the agonist-nuclear receptor complex induces its own hyperphosphorylation as well as the phosphorylation of TFIIEa, TAFII28, and TAFII55. Belongs to a family of nuclear proteins that includes TIF1b and TIF1g. TIF1 proteins are characterized by an N-terminal region that contains a RING finger-B boxes-coiled coil (RBCC) motif, a poorly conserved central region, a C-terminal region that contains a PHD finger, and a bromodomain. Interacts with the heterochromatin-associated proteins HP1a, MOD1 (HP1b), and MOD2 (HP1g) and with the transcriptional repression domain KRAB, which is present in many Kruppel-type (C2H2) zinc finger proteins. May act as a repressor through the formation of transcriptionally inactive heterochromatin. Two splice variant isoforms have been described.
Protein type: Kinase, protein; Nuclear receptor co-regulator; EC 6.3.2.-; Protein kinase, atypical; Ubiquitin conjugating system; Transcription, coactivator/corepressor; Tumor suppressor; ATYPICAL group; TIF1 family
Chromosomal Location of Human Ortholog: 7q32-q34
Cellular Component: nucleoplasm; perichromatin fibrils; nucleus; cytosol
Molecular Function: ligand-dependent nuclear receptor binding; zinc ion binding; p53 binding; transcription coactivator activity; ubiquitin-protein ligase activity; estrogen response element binding; methylated histone residue binding; protein kinase activity; protein binding; sequence-specific DNA binding; chromatin binding; receptor binding; ligase activity
Biological Process: calcium ion homeostasis; transcription from RNA polymerase II promoter; regulation of apoptosis; response to peptide hormone stimulus; negative regulation of cell proliferation; positive regulation of transcription, DNA-dependent; protein amino acid autophosphorylation; protein ubiquitination; regulation of protein stability; protein catabolic process; negative regulation of transcription, DNA-dependent
Disease: Thyroid Carcinoma, Papillary
Research Articles on TRIM24
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Product Notes
The Human TRIM24 trim24 (Catalog #AAA9338240) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9338240 ELISA Kit recognizes Human TRIM24. It is sometimes possible for the material contained within the vial of "tripartite motif-containing 24, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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