Mouse peroxisomal biogenesis factor 5 ELISA Kit | PEX5 elisa kit

Mouse Peroxisomal targeting signal 1 receptor, PEX5 ELISA Kit

Cat. Num. AAA9337847

• Gene Names: Pex5; Pxr1; ESTM1; PTS1R; X83306; AW212715
• Reactivity: Mouse
• Synonyms: peroxisomal biogenesis factor 5; Mouse Peroxisomal targeting signal 1 receptor; PEX5 ELISA Kit; Mouse Peroxisomal targeting signal 1 receptor (PEX5) ELISA kit; FLJ50634; FLJ50721; FLJ51948; PTS1-BP; PTS1R; PXR1; peroxin-5; peroxisomal C-terminal targeting signal import receptor; peroxisomal targeting signal 1 (SKL type) receptor; peroxisomal targeting signal; PEX5 elisa kit

• Reactivity: Mouse

• Assay Type: Quantitative Sandwich
• Detection Range: 0.25ng/ml-8ng/ml
• Sensitivity: 0.1ng/ml
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for PEX5 elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or test applications! This kit is intended to be used for determine the level of PEX5 (hereafter termed "analyte") in undiluted original Mouse serum, plasma or tissue homogenates samples. For other sample types please contact tech support to determine compatibility with this assay. This kit is not suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 472339081
• NCBI GeneID: 19305
• NCBI Accession #: NP_001264259.1
• NCBI GenBank Nucleotide #: NM_001277330.1
• UniProt Accession #: O09012; Q3UM58; Q8K2V5; Q91YC7
• Molecular Weight: 70,756 Da
• NCBI Official Full Name: peroxisomal biogenesis factor 5 isoform 2
• NCBI Official Synonym Full Names: peroxisomal biogenesis factor 5
• NCBI Official Symbol: Pex5
• NCBI Official Synonym Symbols: Pxr1; ESTM1; PTS1R; X83306; AW212715
• NCBI Protein Information: peroxisomal biogenesis factor 5; PXR1P; PTS1-BP; peroxin 5; PTS1 receptor; peroxisome receptor 1; peroxisome biogenesis factor 5; peroxisomal targeting signal 1 receptor; peroxisomal C-terminal targeting signal import receptor
• UniProt Protein Name: Peroxisomal targeting signal 1 receptor
• Protein Family: Peroxisome biogenesis protein
• UniProt Gene Name: Pex5
• UniProt Synonym Gene Names: Pxr1; PTS1 receptor; PTS1R
• UniProt Entry Name: PEX5_MOUSE

Uniprot Description

PEX5: Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Defects in PEX5 are a cause of adrenoleukodystrophy neonatal (NALD). NALD is a peroxisome biogenesis disorder (PBD) characterized by the accumulation of very long- chain fatty acids, adrenal insufficiency and mental retardation. Inheritance is autosomal recessive. Defects in PEX5 are a cause of Zellweger syndrome (ZWS). ZWS is a fatal peroxisome biogenesis disorder characterized by dysmorphic facial features, hepatomegaly, ocular abnormalities, renal cysts, hearing impairment, profound psychomotor retardation, severe hypotonia and neonatal seizures. Death occurs within the first year of life. Defects in PEX5 may be a cause of infantile Refsum disease (IRD). IRD is a mild peroxisome biogenesis disorder (PBD). Clinical features include early onset, mental retardation, minor facial dysmorphism, retinopathy, sensorineural hearing deficit, hepatomegaly, osteoporosis, failure to thrive, and hypocholesterolemia. The biochemical abnormalities include accumulation of phytanic acid, very long chain fatty acids (VLCFA), di- and trihydroxycholestanoic acid and pipecolic acid. Belongs to the peroxisomal targeting signal receptor family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, protein translocating; Membrane protein, integral

Cellular Component: Golgi apparatus; peroxisomal membrane; peroxisomal matrix; protein complex; membrane; mitochondrion; cell; cytoplasm; peroxisome; intracellular; cytosol

Molecular Function: small GTPase binding; protein C-terminus binding; enzyme binding; peroxisome targeting sequence binding; peroxisome matrix targeting signal-1 binding; protein N-terminus binding

Biological Process: endoplasmic reticulum organization and biogenesis; mitochondrion organization and biogenesis; isoprenoid biosynthetic process; mitochondrial membrane organization and biogenesis; neuromuscular process; neuron migration; protein import into peroxisome matrix; cellular lipid metabolic process; positive regulation of multicellular organism growth; cerebral cortex neuron differentiation; protein transport; fatty acid beta-oxidation; cerebral cortex cell migration; very-long-chain fatty acid metabolic process; transport; protein targeting to peroxisome; peroxisome organization and biogenesis; protein import into peroxisome matrix, docking; protein import into peroxisome matrix, translocation; protein import into peroxisome membrane; cell development; protein tetramerization