Mouse X-ray repair complementing defective repair in Chinese hamster cells 3 ELISA Kit | XRCC3 elisa kit
Mouse DNA repair protein XRCC3, XRCC3 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
XRCC3: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C. Defects in XRCC3 are the cause of susceptibility to breast cancer (BC). BC is a common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. Defects in XRCC3 are the cause of susceptibility to cutaneous malignant melanoma type 6 (CMM6). CMM6 is a malignant neoplasm of melanocytes, arising de novo or from a pre- existing benign nevus, which occurs most often in the skin but also may involve other sites. Belongs to the RecA family. RAD51 subfamily.
Protein type: DNA repair, damage
Cellular Component: mitochondrion; perinuclear region of cytoplasm; cytoplasm; replication fork; nucleus
Molecular Function: DNA-dependent ATPase activity; DNA binding; four-way junction DNA binding; nucleotide binding; crossover junction endodeoxyribonuclease activity; ATP binding
Biological Process: DNA repair; DNA catabolic process, endonucleolytic; response to DNA damage stimulus; double-strand break repair via homologous recombination; DNA recombination
Research Articles on XRCC3
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Product Notes
The Mouse XRCC3 xrcc3 (Catalog #AAA9337128) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9337128 ELISA Kit recognizes Mouse XRCC3. It is sometimes possible for the material contained within the vial of "X-ray repair complementing defective repair in Chinese hamster cells 3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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