Mouse ubiquitin protein ligase E3 component n-recognin 2 ELISA Kit | UBR2 elisa kit
Mouse E3 ubiquitin-protein ligase UBR2, UBR2 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
UBR2: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. Belongs to the UBR1 family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin ligase; Ligase; Ubiquitin conjugating system; EC 6.3.2.19; EC 6.3.2.-
Cellular Component: nucleoplasm; plasma membrane; nucleus; chromatin; ubiquitin ligase complex
Molecular Function: protein binding; zinc ion binding; coenzyme F420-2 alpha-glutamyl ligase activity; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity; metal ion binding; ribosomal S6-glutamic acid ligase activity; coenzyme F420-0 gamma-glutamyl ligase activity; ligase activity
Biological Process: ubiquitin-dependent protein catabolic process; negative regulation of TOR signaling pathway; male meiosis I; chromatin silencing; protein ubiquitination; protein catabolic process; spermatogenesis; histone H2A ubiquitination
Research Articles on UBR2
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Product Notes
The Mouse UBR2 ubr2 (Catalog #AAA9336311) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9336311 ELISA Kit recognizes Mouse UBR2. It is sometimes possible for the material contained within the vial of "ubiquitin protein ligase E3 component n-recognin 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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