Mouse suppressor of fused homolog (Drosophila) ELISA Kit | SUFU elisa kit
Mouse Suppressor of fused homolog, SUFU ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
SUFU: a transcriptional regulator which negatively regulates the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. Modulates nuclear-cytoplasmic shuttling of Gli-1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of FUSED to both SUFU and a GLI protein. Mutations in SUFU predispose to medulloblastoma. Part of a DNA-bound corepressor complex containing SAP18, GLI1 and SIN3. Part of a complex containing CTNNB1. Binds BTRC, GLI2, GLI3, SAP18 and STK36. Binds both free and DNA-bound GLI1. Defects in SUFU are a cause of medulloblastoma (MDB). MDB is a malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children. Three alternatively spliced isoforms have been described.
Protein type: Adaptor/scaffold; Tumor suppressor; Transcription, coactivator/corepressor
Cellular Component: nucleoplasm; cell; cytoplasm; nucleus; cilium
Molecular Function: protein binding; beta-catenin binding; protein kinase binding; transcription factor binding
Biological Process: skin development; cytoplasmic sequestering of transcription factor; negative regulation of smoothened signaling pathway; neural tube closure; spinal cord dorsal/ventral patterning; heart looping; negative regulation of transcription from RNA polymerase II promoter; determination of left/right symmetry; smoothened signaling pathway involved in ventral spinal cord interneuron specification; smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
Research Articles on SUFU
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Product Notes
The Mouse SUFU sufu (Catalog #AAA9336069) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9336069 ELISA Kit recognizes Mouse SUFU. It is sometimes possible for the material contained within the vial of "suppressor of fused homolog (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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