Human oligonucleotide/oligosaccharide-binding fold containing 2A ELISA Kit | OBFC2A elisa kit
Human SOSS complex subunit B2, OBFC2A ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]
Uniprot Description
OBFC2A: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Belongs to the SOSS-B family. SOSS-B2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; DNA repair, damage; Cell cycle regulation
Chromosomal Location of Human Ortholog: 2q32.3
Cellular Component: nucleoplasm; cytoplasm; nucleus
Molecular Function: RNA binding; single-stranded DNA binding
Biological Process: mitotic cell cycle checkpoint; response to ionizing radiation; DNA repair; response to DNA damage stimulus; double-strand break repair via homologous recombination
Research Articles on OBFC2A
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Product Notes
The Human OBFC2A nabp1 (Catalog #AAA9335034) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9335034 ELISA Kit recognizes Human OBFC2A. It is sometimes possible for the material contained within the vial of "oligonucleotide/oligosaccharide-binding fold containing 2A, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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