Mouse transmembrane protein 67 ELISA Kit | TMEM67 elisa kit
Mouse Meckelin, TMEM67 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
TMEM67: a protein localizes to the primary cilium and to the plasma membrane. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC). Ciliary dysfunction leads to a broad spectrum of disorders, collectively termed ciliopathies. Defects in this protein are a cause of Meckel syndrome type 3 (MKS3) and Joubert syndrome type 6 (JBTS6). Overlapping clinical features include retinal degeneration, renal cystic disease, skeletal abnormalities, fibrosis of various organ, and a complex range of anatomical and functional defects of the central and peripheral nervous system. Interacts with DNAJB9, DNAJC10, MKS1 and mutated SFTPC. Interacts with SYNE2 during the early establishment of cell polarity.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: centrosome; endoplasmic reticulum membrane; cytoskeleton; cell projection; cytoplasmic vesicle membrane; membrane; endoplasmic reticulum; cytoplasm; plasma membrane; integral to membrane; cilium
Molecular Function: unfolded protein binding; filamin binding
Biological Process: ER-associated protein catabolic process; cell projection organization and biogenesis; branching morphogenesis of a tube; cilium biogenesis
Disease: Bardet-biedl Syndrome 1
Research Articles on TMEM67
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Product Notes
The Mouse TMEM67 tmem67 (Catalog #AAA9334739) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9334739 ELISA Kit recognizes Mouse TMEM67. It is sometimes possible for the material contained within the vial of "transmembrane protein 67, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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