Human toll-like receptor adaptor molecule 2 ELISA Kit | TICAM2 elisa kit
Human TIR domain-containing adapter molecule 2, TICAM2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010]
Uniprot Description
TICAM2: a toll-like receptor adapter that participates in induction of type 1 interferons. Transiently phosphorylated on serine-16 during LPS/Toll-like receptor 4 (TLR4) signaling. Activated TLR4 associates with four adapter proteins, MyD88, TIRAP, TICAM-1 (Trif), and TICAM-2.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 5q23.1
Cellular Component: Golgi apparatus; late endosome membrane; early endosome membrane; endoplasmic reticulum; early endosome; late endosome; plasma membrane; endosome membrane
Molecular Function: signal transducer activity; phospholipid binding
Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of interferon-gamma production; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; negative regulation of toll-like receptor 4 signaling pathway; positive regulation of toll-like receptor 4 signaling pathway; toll-like receptor signaling pathway; positive regulation of interleukin-6 production; innate immune response; toll-like receptor 3 signaling pathway; inflammatory response; toll-like receptor 4 signaling pathway
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Product Notes
The Human TICAM2 ticam2 (Catalog #AAA9334100) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9334100 ELISA Kit recognizes Human TICAM2. It is sometimes possible for the material contained within the vial of "toll-like receptor adaptor molecule 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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