Mouse SIX homeobox 1 ELISA Kit | SIX1 elisa kit
Mouse Homeobox protein SIX1, SIX1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
SIX1: May be involved in limb tendon and ligament development. Defects in SIX1 are the cause of deafness autosomal dominant type 23 (DFNA23). A form of non-syndromic deafness characterized by prelingual, bilateral, symmetric hearing loss with a conductive component present in some but not all patients. Defects in SIX1 are the cause of branchiootic syndrome type 3 (BOS3). BOS3 is a syndrome characterized by usually bilateral branchial cleft fistulas or cysts, sensorineural and/or conductive hearing loss, pre-auricular pits, and structural defects of the outer, middle or inner ear. Otic defects include malformed and hypoplastic pinnae, a narrowed external ear canal, bulbous internal auditory canal, stapes fixation, malformed and hypoplastic cochlea. Branchial and otic anomalies are as those seen in individuals with the branchiootorenal syndrome. However, renal anomalies are absent in branchiootic syndrome patients. Defects in SIX1 could be a cause of branchiootorenal syndrome (BOR). BOR is an autosomal dominant disorder manifested by various combinations of preauricular pits, branchial fistulae or cysts, lacrimal duct stenosis, hearing loss, structural defects of the outer, middle, or inner ear, and renal dysplasia. Associated defects include asthenic habitus, long narrow facies, constricted palate, deep overbite, and myopia. Hearing loss may be due to mondini type cochlear defect and stapes fixation. Penetrance of BOR syndrome is high, although expressivity can be extremely variable. Belongs to the SIX/Sine oculis homeobox family.
Protein type: Cell development/differentiation; Transcription factor; DNA-binding
Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; chromatin binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; tongue development; regulation of neuron differentiation; apoptosis; anatomical structure development; multicellular organismal development; positive regulation of transcription, DNA-dependent; middle ear morphogenesis; negative regulation of transcription from RNA polymerase II promoter; olfactory placode formation; regulation of epithelial cell proliferation; sensory perception of sound; regulation of protein localization; regulation of transcription, DNA-dependent; epithelial cell differentiation; ureteric bud development; induction of an organ; thyroid gland development; neuron fate specification; regulation of synaptic growth at neuromuscular junction; negative regulation of neuron apoptosis; kidney development; inner ear development; skeletal muscle development; inner ear morphogenesis; pharyngeal system development; thymus development; transcription, DNA-dependent; facial nerve morphogenesis; embryonic cranial skeleton morphogenesis; pattern specification process; embryonic skeletal morphogenesis; neurogenesis; generation of neurons; regulation of gene expression; ureteric bud branching; skeletal morphogenesis; myoblast migration; positive regulation of transcription from RNA polymerase II promoter; regulation of satellite cell proliferation; negative regulation of apoptosis
Research Articles on SIX1
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Product Notes
The Mouse SIX1 six1 (Catalog #AAA9333743) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9333743 ELISA Kit recognizes Mouse SIX1. It is sometimes possible for the material contained within the vial of "SIX homeobox 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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