Mouse adenosine deaminase, RNA-specific ELISA Kit | ADAR elisa kit
Mouse Double-stranded RNA-specific adenosine deaminase, ADAR ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
ADAR: Converts multiple adenosines to inosines and creates I/U mismatched base pairs in double-helical RNA substrates without apparent sequence specificity. Has been found to modify more frequently adenosines in AU-rich regions, probably due to the relative ease of melting A/U base pairs as compared to G/C pairs. Functions to modify viral RNA genomes and may be responsible for hypermutation of certain negative-stranded viruses. Edits the messenger RNAs for glutamate receptor (GLUR) subunits by site- selective adenosine deamination. Produces low-level editing at the GLUR-B Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. Binds to ILF3/NF90 and up-regulates ILF3-mediated gene expression. Isoform 1 is induced by interferon alpha. Isoform 5 is constitutively expressed. Homodimer. Isoform 1 interacts with ILF2/NF45 and ILF3/NF90. 5 isoforms of the human protein are produced by alternative promoter.
Protein type: Nucleolus; EC 3.5.4.37; RNA-binding; Hydrolase; RNA processing
Cellular Component: nucleoplasm; membrane; cytoplasm; nucleolus; nucleus
Molecular Function: adenosine deaminase activity; double-stranded RNA adenosine deaminase activity; protein binding; DNA binding; left-handed Z-DNA binding; hydrolase activity; RNA binding; metal ion binding; double-stranded RNA binding
Biological Process: positive regulation of viral genome replication; base conversion or substitution editing; transcription, DNA-dependent; in utero embryonic development; immune system process; response to virus; miRNA-mediated gene silencing, miRNA loading onto RISC; somatic diversification of immune receptors via somatic mutation; adenosine to inosine editing; RNA processing; osteoblast differentiation; miRNA-mediated gene silencing, production of miRNAs; regulation of transcription, DNA-dependent; negative regulation of viral genome replication; pre-microRNA processing; protein import into nucleus; erythrocyte differentiation; innate immune response; RNA-mediated gene silencing; hemopoietic progenitor cell differentiation; protein export from nucleus; mRNA processing; defense response to virus; negative regulation of apoptosis
Research Articles on ADAR
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Product Notes
The Mouse ADAR adar (Catalog #AAA9332900) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9332900 ELISA Kit recognizes Mouse ADAR. It is sometimes possible for the material contained within the vial of "adenosine deaminase, RNA-specific, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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