Human Dynamin-1-Like Protein (DNM1L) ELISA Kit | DNM1L elisa kit

Human Dynamin-1-Like Protein (DNM1L) ELISA Kit

Cat. Num. AAA9332652

• Gene Names: DNM1L; DLP1; DRP1; DVLP; EMPF; DYMPLE; HDYNIV
• Reactivity: Human
• Synonyms: Dynamin-1-Like Protein (DNM1L); Human Dynamin-1-Like Protein (DNM1L) ELISA Kit; Human Dynamin-1-like protein (DNM1L) ELISA kit; DLP1; DRP1; DVLP; DYMPLE; DYNIV-11; FLJ41912; HDYNIV; VPS1; Dnm1p/Vps1p-like protein; dynamin family member proline-rich carboxyl-terminal domain less; dynamin-like protein 4; dynamin-like protein IV; d; dynamin 1-like; DNM1L elisa kit

• Reactivity: Human

• Assay Type: Quantitative Sandwich
• Detection Range: 3.12ng/ml-100ng/ml
• Sensitivity: 1.0ng/ml
• Intra-assay Precision: Intra-assay CV (%)is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for DNM1L elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or test applications! This kit is intended to be used for determine the level of DNM1L (hereafter termed "analyte") in undiluted original Human serum, plasma or tissue homogenates samples. For other sample types please contact tech support to determine compatibility with this assay. This kit is not suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 510937022
• NCBI GeneID: 10059
• NCBI Accession #: NP_001265392.1
• NCBI GenBank Nucleotide #: NM_001278463.1
• UniProt Accession #: O00429
• NCBI Official Full Name: dynamin-1-like protein isoform 4
• NCBI Official Synonym Full Names: dynamin 1-like
• NCBI Official Symbol: DNM1L
• NCBI Official Synonym Symbols: DLP1; DRP1; DVLP; EMPF; DYMPLE; HDYNIV
• NCBI Protein Information: dynamin-1-like protein; dynamin-like protein 4; dynamin-like protein IV; Dnm1p/Vps1p-like protein; dynamin-related protein 1; dynamin family member proline-rich carboxyl-terminal domain less
• UniProt Protein Name: Dynamin-1-like protein
• Protein Family: Dynamin-1-like protein
• UniProt Gene Name: DNM1L
• UniProt Synonym Gene Names: DLP1; DRP1; DVLP; Dymple; HdynIV

NCBI Description

This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

Uniprot Description

Function: Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues. Also required for mitochondrial fission during mitosis. Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution.20 PublicationsManual assertion based on experiment in:Ref.3

Catalytic activity: GTP + H2O = GDP + phosphate.2 PublicationsManual assertion based on experiment in:Ref.9

Enzyme regulation: GTPase activity is increased by binding to phospholipid membranes.1 PublicationManual assertion based on experiment in:Ref.47