Human dishevelled, dsh homolog 2 (Drosophila) ELISA Kit | DVL2 elisa kit
Human Segment polarity protein dishevelled homolog DVL-2, DVL2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]
Uniprot Description
DVL2: a protein in the WNT/planar cell polarity (PCP) signaling pathway. Dvl2-deficient mice indicate that Dvl2 is essential for normal cardiac morphogenesis, somite segmentation and neural tube closure. Transduces the Wnt signal by interacting with the cytoplasmic Axin complex. Dvl and Axin each contain a DIX domains, which mediate their dynamic polymerization. The Dvl-Axin interaction is essential for Wnt signaling. Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Dixin and Rac. There is functional redundancy between Dvl1 and Dvl2 in some phenotypes.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: apical part of cell; cytoplasm; plasma membrane; cytoplasmic vesicle; clathrin-coated endocytic vesicle; nucleus; cytosol
Molecular Function: identical protein binding; protein domain specific binding; protein binding; protein self-association; frizzled binding
Biological Process: segment specification; transcription from RNA polymerase II promoter; positive regulation of JNK activity; Wnt receptor signaling pathway; convergent extension involved in neural plate elongation; Wnt receptor signaling pathway, planar cell polarity pathway; positive regulation of transcription, DNA-dependent; heart development; neural tube closure; positive regulation of transcription factor activity; positive regulation of protein amino acid phosphorylation; Wnt receptor signaling pathway through beta-catenin
Research Articles on DVL2
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Product Notes
The Human DVL2 dvl2 (Catalog #AAA9332533) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9332533 ELISA Kit recognizes Human DVL2. It is sometimes possible for the material contained within the vial of "dishevelled, dsh homolog 2 (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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