Human ring finger and CCCH-type zinc finger domains 1 ELISA Kit | RC3H1 elisa kit
Human Roquin, RC3H1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein containing RING-type and C3H1-type zinc finger motifs. The encoded protein recognizes and binds to a constitutive decay element (CDE) in the 3' UTR of mRNAs, leading to mRNA deadenylation and degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Description
RC3H1: Represses ICOS function, an essential costimulatory receptor for follicular T-cells. May act as an ubiquitin ligase that regulates ubiquitin-dependent control of AU-rich mRNAs by AUF1/HNRPD and HUR/ELAVL1. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA-binding; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 1q25.1
Cellular Component: stress granule
Molecular Function: mRNA 3'-UTR binding; zinc ion binding
Biological Process: spleen development; negative regulation of germinal center formation; negative regulation of activated T cell proliferation; protein ubiquitination; negative regulation of B cell proliferation; regulation of mRNA stability; lymph node development; regulation of germinal center formation; T cell proliferation; negative regulation of T-helper cell differentiation; B cell homeostasis; regulation of T cell receptor signaling pathway; cytoplasmic mRNA processing body assembly; T cell homeostasis
Research Articles on RC3H1
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Product Notes
The Human RC3H1 rc3h1 (Catalog #AAA9332084) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9332084 ELISA Kit recognizes Human RC3H1. It is sometimes possible for the material contained within the vial of "ring finger and CCCH-type zinc finger domains 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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