Mouse inositol 1, 3, 4-triphosphate 5/6 kinase ELISA Kit | ITPK1 elisa kit
Mouse Inositol-tetrakisphosphate 1-kinase, ITPK1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
ITPK1: Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain. Belongs to the ITPK1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.7.1.134; Carbohydrate Metabolism - inositol phosphate; Kinase, lipid; EC 2.7.1.159; Motility/polarity/chemotaxis
Cellular Component: intracellular
Molecular Function: transferase activity; hydrolase activity; metal ion binding; magnesium ion binding; nucleotide binding; inositol tetrakisphosphate 1-kinase activity; kinase activity; isomerase activity; ATP binding
Biological Process: phosphorylation; inositol trisphosphate metabolic process
Research Articles on ITPK1
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Product Notes
The Mouse ITPK1 itpk1 (Catalog #AAA9331777) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9331777 ELISA Kit recognizes Mouse ITPK1. It is sometimes possible for the material contained within the vial of "inositol 1, 3, 4-triphosphate 5/6 kinase, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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