Mouse tripartite motif-containing 11 ELISA Kit | TRIM11 elisa kit
Mouse E3 ubiquitin-protein ligase TRIM11, TRIM11 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
TRIM11: E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle. Belongs to the TRIM/RBCC family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Ligase; Ubiquitin conjugating system; EC 6.3.2.19; EC 6.3.2.-; Ubiquitin ligase
Cellular Component: cytoplasm; intracellular; nucleus
Molecular Function: protein domain specific binding; protein binding; zinc ion binding; coenzyme F420-2 alpha-glutamyl ligase activity; metal ion binding; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity; ubiquitin-protein ligase activity; ribosomal S6-glutamic acid ligase activity; coenzyme F420-0 gamma-glutamyl ligase activity; transcription factor binding; ligase activity
Biological Process: negative regulation of viral transcription; positive regulation of virion penetration into host cell; negative regulation of virion penetration into host cell; protein ubiquitination; innate immune response; negative regulation of transcription, DNA-dependent; defense response to virus; negative regulation of neurogenesis
Research Articles on TRIM11
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Product Notes
The Mouse TRIM11 trim11 (Catalog #AAA9331714) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9331714 ELISA Kit recognizes Mouse TRIM11. It is sometimes possible for the material contained within the vial of "tripartite motif-containing 11, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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