Rat neuronal guanine nucleotide exchange factor ELISA Kit | NGEF elisa kit
Rat Ephexin-1, NGEF ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
ephexin-1: Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension. Interacts with CDK5R1 and EPHA4; activated by EPHA4 through the CDK5 kinase. Highly expressed in brain specifically in caudate nucleus and to a lower extent in amygdala and hippocampus. Also detected in lung. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GEFs, Rac/Rho; GEFs
Cellular Component: cell projection; growth cone; membrane; cytoplasm
Molecular Function: Rho guanyl-nucleotide exchange factor activity; protein binding; ephrin receptor binding; guanyl-nucleotide exchange factor activity
Biological Process: nervous system development; regulation of GTPase activity; multicellular organismal development; regulation of Rho protein signal transduction; ephrin receptor signaling pathway; cell differentiation; cellular process; positive regulation of GTPase activity
Research Articles on NGEF
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Product Notes
The Rat NGEF ngef (Catalog #AAA9330153) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9330153 ELISA Kit recognizes Rat NGEF. It is sometimes possible for the material contained within the vial of "neuronal guanine nucleotide exchange factor, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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