Human membrane-associated ring finger (C3HC4) 1 ELISA Kit | MARCH1 elisa kit
Human E3 ubiquitin-protein ligase MARCH1, MARCH1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]).[supplied by OMIM, Mar 2010]
Uniprot Description
MARCH1: E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ligase; Membrane protein, multi-pass; Membrane protein, integral; EC 6.3.2.19; Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.-
Chromosomal Location of Human Ortholog: 4q32.2
Cellular Component: endoplasmic reticulum membrane; cytoplasmic vesicle membrane; lysosome; early endosome membrane; lysosomal membrane; late endosome membrane; plasma membrane; integral to membrane; trans-Golgi network membrane; endosome
Molecular Function: zinc ion binding; ubiquitin-protein ligase activity; MHC protein binding; ligase activity
Biological Process: protein polyubiquitination; antigen processing and presentation of peptide antigen via MHC class II; immune response
Research Articles on MARCH1
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Product Notes
The Human MARCH1 march1 (Catalog #AAA9329124) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9329124 ELISA Kit recognizes Human MARCH1. It is sometimes possible for the material contained within the vial of "membrane-associated ring finger (C3HC4) 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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