Mouse von Hippel-Lindau tumor suppressor ELISA Kit | VHL elisa kit
Mouse Von Hippel-Lindau disease tumor suppressor, VHL ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
VHL: Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. Component of the VCB (VHL-Elongin BC-CUL2) complex; this complex acts as a ubiquitin-ligase E3 and directs proteasome- dependent degradation of targeted proteins. Interacts with CUL2; this interaction is dependent on the integrity of the trimeric VBC complex. Interacts (via the beta domain) with HIF1A (via the NTAD domain); this interaction mediates degradation of HIF1A in normoxia and, in hypoxia, prevents ubiqitination and degradation of HIF1A by mediating hypoxia-induced translocation to the nucleus, a process which requires a hypoxia-dependent regulatory signal. Interacts with ADRB2; the interaction, in normoxia, is dependent on hydroxylation of ADRB2 and the subsequent VCB- mediated ubiquitination and degradation of ADRB2. Under hypoxia, hydroxylation, interaction with VHL, ubiquitination and subsequent degradation of ADRB2 are dramatically decreased. Interacts with RNF139, USP33 and PHF17. Found in a complex composed of LIMD1, VHL, EGLN1/PHD2, TCEB2 AND CUL2. Isoform 1 and isoform 3 interact with LIMD1 (via LIM zinc-binding 2), AJUBA (via LIM domains) and WTIP (via LIM domains). Interacts with EPAS1. Expressed in the adult and fetal brain and kidney. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin ligase; Tumor suppressor
Cellular Component: nucleoplasm; Cul2-RING ubiquitin ligase complex; intermediate filament cytoskeleton; mitochondrion; membrane; cell; VCB complex; cytoplasm; nucleolus; intracellular; nucleus; cytosol; cilium
Molecular Function: protein binding; enzyme binding; protein complex binding; transcription factor binding
Biological Process: proteasomal protein catabolic process; extracellular matrix organization and biogenesis; blood vessel endothelial cell migration; protein heterooligomerization; positive regulation of transcription, DNA-dependent; regulation of catecholamine metabolic process; protein ubiquitination; negative regulation of transcription from RNA polymerase II promoter; NLS-bearing substrate import into nucleus; neuron differentiation; protein transport; regulation of transcription, DNA-dependent; response to hypoxia; protein catabolic process; angiogenesis
Research Articles on VHL
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Product Notes
The Mouse VHL vhl (Catalog #AAA9328482) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9328482 ELISA Kit recognizes Mouse VHL. It is sometimes possible for the material contained within the vial of "von Hippel-Lindau tumor suppressor, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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