Human solute carrier family 34 (sodium phosphate) , member 3 ELISA Kit | SLC34A3 elisa kit
Human Sodium-dependent phosphate transport protein 2C, SLC34A3 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of SLC34A transporter family of proteins, and is expressed primarily in the kidney. It is involved in transporting phosphate into cells via sodium cotransport in the renal brush border membrane, and contributes to the maintenance of inorganic phosphate concentration in the kidney. Mutations in this gene are associated with hereditary hypophosphatemic rickets with hypercalciuria. Alternatively spliced transcript variants varying in the 5' UTR have been found for this gene.[provided by RefSeq, Apr 2010]
Uniprot Description
SLC34A3: May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 20-30% of the apical influx. Defects in SLC34A3 are the cause of hereditary hypophosphatemic rickets with hypercalciuria (HHRH). HHRH is an autosomal recessive form of hypophosphatemia characterized by reduced renal phosphate reabsorption and rickets. Increased serum levels of 1,25-dihydroxyvitamin D lead to increase in urinary calcium excretion. Belongs to the SLC34A transporter family.
Protein type: Transporter; Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 9q34
Cellular Component: brush border membrane; apical plasma membrane; integral to membrane; plasma membrane
Molecular Function: sodium-dependent phosphate transmembrane transporter activity; sodium:phosphate symporter activity
Biological Process: cellular phosphate ion homeostasis; phosphate transport; sodium ion transport; ion transport; transmembrane transport
Disease: Hypophosphatemic Rickets With Hypercalciuria, Hereditary
Research Articles on SLC34A3
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Product Notes
The Human SLC34A3 slc34a3 (Catalog #AAA9328133) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9328133 ELISA Kit recognizes Human SLC34A3. It is sometimes possible for the material contained within the vial of "solute carrier family 34 (sodium phosphate) , member 3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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