Human solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter) , member 8 ELISA Kit | SLC17A8 elisa kit
Human Vesicular glutamate transporter 3, SLC17A8 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a vesicular glutamate transporter. The encoded protein transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft. Mutations in this gene are the cause of autosomal-dominant nonsyndromic type 25 deafness. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Uniprot Description
SLC17A8: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Defects in SLC17A8 are the cause of deafness autosomal dominant type 25 (DFNA25). DFNA25 is a form of sensorineural hearing loss. The expression of DFNA25 deafness is variable in terms of onset and rate of progression, with an age- dependent penetrance resembling an early-onset presbycusis, or senile deafness, a progressive bilateral loss of hearing that occurs in the aged. Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, SLC family; Membrane protein, multi-pass; Transporter
Chromosomal Location of Human Ortholog: 12q23.1
Cellular Component: neuron projection; synaptic vesicle membrane; integral to membrane; cell junction
Molecular Function: symporter activity; L-glutamate transmembrane transporter activity
Biological Process: sensory perception of sound; neurotransmitter transport; sodium ion transport; ion transport; transmembrane transport
Disease: Deafness, Autosomal Dominant 25
Research Articles on SLC17A8
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Product Notes
The Human SLC17A8 slc17a8 (Catalog #AAA9327476) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9327476 ELISA Kit recognizes Human SLC17A8. It is sometimes possible for the material contained within the vial of "solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter) , member 8, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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