Human ubiquitin-conjugating enzyme E2W (putative) ELISA Kit | UBE2W elisa kit

Human Probable ubiquitin-conjugating enzyme E2 W, UBE2W ELISA Kit

Cat. Num. AAA9326919

• Gene Names: UBE2W; UBC16; UBC-16
• Reactivity: Human
• Synonyms: ubiquitin-conjugating enzyme E2W (putative); Human Probable ubiquitin-conjugating enzyme E2 W; UBE2W ELISA Kit; Human Probable ubiquitin-conjugating enzyme E2 W (UBE2W) ELISA kit; FLJ11011; hUBC-16; ubiquitin-conjugating enzyme 16; ubiquitin-conjugating enzyme E2W; UBE2W elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 402169567
• NCBI GeneID: 55284
• NCBI Accession #: NP_001001481.2
• NCBI GenBank Nucleotide #: NM_001001481.2
• UniProt Accession #: Q96B02; Q1XBE0; Q9H823; Q9HAG6; Q9NV07; B4DIV1
• Molecular Weight: 20,689 Da
• NCBI Official Full Name: ubiquitin-conjugating enzyme E2 W isoform 1
• NCBI Official Synonym Full Names: ubiquitin-conjugating enzyme E2W (putative)
• NCBI Official Symbol: UBE2W
• NCBI Official Synonym Symbols: UBC16; UBC-16
• NCBI Protein Information: ubiquitin-conjugating enzyme E2 W; N-terminus-conjugating E2; ubiquitin-protein ligase W; ubiquitin carrier protein W; ubiquitin-conjugating enzyme 16; ubiquitin-conjugating enzyme 2W
• UniProt Protein Name: Ubiquitin-conjugating enzyme E2 W
• Protein Family: Ubiquitin-conjugating enzyme
• UniProt Gene Name: UBE2W
• UniProt Synonym Gene Names: UBC16; UBC-16
• UniProt Entry Name: UBE2W_HUMAN

NCBI Description

This gene encodes a nuclear-localized ubiquitin-conjugating enzyme (E2) that, along with ubiquitin-activating (E1) and ligating (E3) enzymes, coordinates the addition of a ubiquitin moiety to existing proteins. The encoded protein promotes the ubiquitination of Fanconi anemia complementation group proteins and may be important in the repair of DNA damage. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Uniprot Description

UBE2W: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Belongs to the ubiquitin-conjugating enzyme family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.19; Ubiquitin conjugating system; Enzyme, misc.; Ligase; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 8q21.11

Cellular Component: cytoplasm; nucleus

Molecular Function: small conjugating protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; ATP binding; ligase activity

Biological Process: protein monoubiquitination; proteasomal ubiquitin-dependent protein catabolic process; misfolded or incompletely synthesized protein catabolic process; DNA repair