Mouse HIR histone cell cycle regulation defective homolog A (S. cerevisiae) ELISA Kit | HIRA elisa kit
Mouse Protein HIRA, HIRA ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
HIRA: a histone chaperone. Necessary to mediate DNA-synthesis-independent nucleosome assembly. Interacts with UBN1, CABIN, and ASF1A in the cell nucleus to form the evolutionarily conserved HUCA histone chaperone complex that deposits the variant histone H3.3 into chromatin in a DNA-replication independent manner. Required for deposition of histone H3.3 at the transcription start sites of genes, where incorporation of histone H3.3 facilitates nucleosome destabilization and contributes to transcriptional activation. Histone H3.3 is also linked to gene silencing and is incorporated into regions of the genome thought to be transcriptionally inactive. While some incorporation of H3.3 into heterochromatin is facilitated by an additional histone chaperone complex containing ATRX and DAXX (ie. telomeric incorporation of H3.3), HIRA is required for incorporation of histone H3.3 and formation of senescence-associated heterochromatin foci (SAHF) during cellular senescence. HIRA is ubiquitously expressed during mouse embryonic development. In the adult mouse, HIRA is expressed at high levels in the kidney, skeletal muscle, and pancreas, but it is expressed at lower levels in the heart, lung, placenta, brain, and liver. A missing copy of the HIRA gene on human chromosome region 22q11.2 is a common characteristic of DiGeorge syndrome patients and insufficient production of the HIRA protein may disrupt normal embryonic development. Two isoforms of the human protein result from alternative splicing.
Protein type: Cell development/differentiation; Transcription regulation; Cell cycle regulation
Cellular Component: nucleoplasm; protein complex; nuclear chromatin; nucleus
Molecular Function: protein binding; chromatin binding
Biological Process: osteoblast differentiation; muscle cell differentiation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; DNA replication-independent nucleosome assembly; gastrulation; chromatin modification
Research Articles on HIRA
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Product Notes
The Mouse HIRA hira (Catalog #AAA9326435) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9326435 ELISA Kit recognizes Mouse HIRA. It is sometimes possible for the material contained within the vial of "HIR histone cell cycle regulation defective homolog A (S. cerevisiae), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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