Mouse iroquois homeobox 5 ELISA Kit | IRX5 elisa kit
Mouse Iroquois-class homeodomain protein IRX-5, IRX5 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
IRX5: Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina. Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12. Defects in IRX5 are the cause of Hamamy syndrome (HMMS). A sydrome characterized by severe hypertelorism, upslanting palpebral fissures, brachycephaly, abnormal ears, sloping shoulders, enamel hypoplasia, and osteopenia with repeated fractures. Additional features include myopia, mild to moderate sensorineural hearing loss, gonadal anomalies, and borderline intelligence. Belongs to the TALE/IRO homeobox family.
Protein type: DNA-binding
Cellular Component: nucleus
Molecular Function: DNA binding; sequence-specific DNA binding
Biological Process: transcription, DNA-dependent; visual perception; regulation of transcription, DNA-dependent; regulation of heart rate; regulation of gene expression; response to stimulus; neuron maturation; cell development; retinal bipolar neuron differentiation
Research Articles on IRX5
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Product Notes
The Mouse IRX5 irx5 (Catalog #AAA9326018) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9326018 ELISA Kit recognizes Mouse IRX5. It is sometimes possible for the material contained within the vial of "iroquois homeobox 5, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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