Rat peptidylglycine alpha-amidating monooxygenase ELISA Kit | PAM elisa kit
Rat Peptidyl-glycine alpha-amidating monooxygenase, PAM ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
catalyzes conversion of glycine-extended peptides into biologically active alpha-amidated peptides [RGD, Feb 2006]
Uniprot Description
PAM: Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.14.17.3; Membrane protein, integral; Lyase; Vesicle; Oxidoreductase; EC 4.3.2.5
Cellular Component: extracellular space; neuron projection; cell surface; cell soma; membrane; perinuclear region of cytoplasm; secretory granule membrane; integral to membrane; plasma membrane; perikaryon; trans-Golgi network; secretory granule
Molecular Function: protein binding; copper ion binding; zinc ion binding; L-ascorbic acid binding; peptidylamidoglycolate lyase activity; calcium ion binding; protein kinase binding; peptidylglycine monooxygenase activity
Biological Process: limb development; response to drug; lactation; maternal process involved in pregnancy; central nervous system development; heart development; response to glucocorticoid stimulus; long-chain fatty acid metabolic process; response to estradiol stimulus; regulation of transcription from RNA polymerase II promoter; ovulation cycle process; odontogenesis; regulation of protein secretion; peptide metabolic process; response to copper ion; peptide amidation; regulation of actin cytoskeleton organization and biogenesis; toxin metabolic process; protein metabolic process; response to hypoxia; protein homooligomerization; protein amino acid amidation; response to pH
Research Articles on PAM
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Product Notes
The Rat PAM pam (Catalog #AAA9325946) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9325946 ELISA Kit recognizes Rat PAM. It is sometimes possible for the material contained within the vial of "peptidylglycine alpha-amidating monooxygenase, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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