Rat nuclear receptor subfamily 4, group A, member 1 ELISA Kit | NR4A1 elisa kit

Rat Nuclear receptor subfamily 4 group A member 1, NR4A1 ELISA Kit

Cat. Num. AAA9325897

• Gene Names: Nr4a1; HMR; Nur77; Ngfi-b
• Reactivity: Rat
• Synonyms: nuclear receptor subfamily 4; group A; member 1; Rat Nuclear receptor subfamily 4 group A member 1; NR4A1 ELISA Kit; Rat Nuclear receptor subfamily 4 group A member 1 (NR4A1) ELISA kit; GFRP1; HMR; MGC9485; N10; NAK-1; NGFIB; NP10; NUR77; TR3; OTTHUMP00000197256; TR3 orphan receptor; early response protein NAK1; growth factor-inducible nuclear protein N10; hormone receptor; orphan nucle; NR4A1 elisa kit

• Reactivity: Rat

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 399498497
• NCBI GeneID: 79240
• NCBI Accession #: NP_077364.2
• NCBI GenBank Nucleotide #: NM_024388.2
• UniProt Accession #: P22829; Q4V8M4
• Molecular Weight: 64,282 Da
• NCBI Official Full Name: nuclear receptor subfamily 4 group A member 1
• NCBI Official Synonym Full Names: nuclear receptor subfamily 4, group A, member 1
• NCBI Official Symbol: Nr4a1
• NCBI Official Synonym Symbols: HMR; Nur77; Ngfi-b
• NCBI Protein Information: nuclear receptor subfamily 4 group A member 1; Orphan nuclear receptor HMR; nerve growth factor induced protein I-B; nerve growth factor-induced protein I-B; immediate early gene transcription factor NGFI-B
• UniProt Protein Name: Nuclear receptor subfamily 4 group A member 1
• Protein Family: Nuclear receptor subfamily
• UniProt Gene Name: Nr4a1
• UniProt Synonym Gene Names: Hmr; Ngfib; NGFI-B
• UniProt Entry Name: NR4A1_RAT

NCBI Description

putative ligand-dependent transcriptional activator [RGD, Feb 2006]

Uniprot Description

Nur77: an orphan nuclear receptor and immediate-early gene that regulates cellular proliferation, apoptosis, inflammation, and glucose metabolism. Induced by exercise in muscle and is a functional regulator of glucose metabolism in skeletal muscle. Its level decreases in the muscle of obese insulin-resistant men. Acts concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. A mediator of TCR-directed thymocyte apoptosis. TCR-signaling induces a FAIM/Akt/Nur77 signaling pathway that is critical for modulating apoptosis in developing thymocytes. A physiological substrate of the MEK-ERK-RSK cascade that modulates nuclear export and intracellular translocation during T cell death. Binds DNA as a monomer. Interacts with GADD45GIP1. Overexpression of Nur77 induces the expression of both p300 and HDAC1. Acetylation by p300 and HDAC1 may regulate the rapid turnover of Nur77 protein.

Protein type: Apoptosis; DNA-binding; Nuclear receptor

Cellular Component: nucleoplasm; transcription factor complex; nuclear membrane; cytoplasm; nucleus

Molecular Function: ligand-dependent nuclear receptor activity; protein homodimerization activity; DNA binding; zinc ion binding; sequence-specific DNA binding; protein heterodimerization activity; steroid hormone receptor activity

Biological Process: transcription from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; cell migration during sprouting angiogenesis; positive regulation of apoptosis; apoptosis; positive regulation of transcription, DNA-dependent; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation; negative regulation of caspase activity