Mouse polo-like kinase 1 (Drosophila) ELISA Kit | PLK1 elisa kit
Mouse Serine/threonine-protein kinase PLK1, PLK1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and may play a role in DNA replication during S phase. This gene is expressed in all embryonic tissues, but restricted to thymus and ovaries in adult tissues. Homozygous knockout mice were embryonic lethal, suggesting that this gene is important for early embryonic development. This gene is thought to be a potential oncogene because it is overexpressed in a variety of tumors and tumor cell lines. Depletion of this protein in cancer cells has been shown to inhibit cell proliferation and suppress oncogenic transformation; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015]
Uniprot Description
PLK1: a kinase of the PLK family. Contains a polo-box domain (PBD), a specific phosphoserine or phosphothreonine binding domain. Substrates include BRCA2, Myt1, NudC, Cdc25C, cyclin B1, Nlp and other mitotic proteins. Inhibited by ATR. Plays a role in regulation of cytokinesis and coordinating M-phase events.
Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.21; Kinase, protein; Protein kinase, Other; Other group; PLK family
Cellular Component: spindle pole; centrosome; chromosome; synaptonemal complex; kinetochore; microtubule cytoskeleton; cytoskeleton; spindle microtubule; cytoplasm; nucleolus; spindle; spindle midzone; midbody; nucleus; chromatin; condensed nuclear chromosome, pericentric region; chromosome, pericentric region
Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; microtubule binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; protein kinase binding; ATP binding; protein kinase activity
Biological Process: positive regulation of proteolysis; regulation of mitotic cell cycle; protein ubiquitination; anaphase-promoting complex activation during mitotic cell cycle; cytokinesis; negative regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; establishment of protein localization; cytokinesis after mitosis; centrosome organization and biogenesis; positive regulation of ubiquitin-protein ligase activity; mitotic cell cycle spindle assembly checkpoint; female meiosis chromosome segregation; G2/M transition of mitotic cell cycle; mitosis; mitotic sister chromatid segregation; protein destabilization; regulation of mitotic metaphase/anaphase transition; negative regulation of cyclin-dependent protein kinase activity; cell cycle; peptidyl-serine phosphorylation; homologous chromosome segregation; cell division; regulation of protein binding; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; polar body extrusion after meiotic divisions; G2/M transition DNA damage checkpoint; phosphorylation; microtubule bundle formation; negative regulation of apoptosis
Research Articles on PLK1
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Product Notes
The Mouse PLK1 plk1 (Catalog #AAA9325821) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9325821 ELISA Kit recognizes Mouse PLK1. It is sometimes possible for the material contained within the vial of "polo-like kinase 1 (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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