Mouse EF-hand calcium binding domain 4B ELISA Kit | EFCAB4B elisa kit
Mouse EF-hand calcium-binding domain-containing protein 4B, EFCAB4B ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
EFCAB4B: Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. Belongs to the EFCAB4 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Calcium-binding
Cellular Component: Golgi apparatus; membrane; cytoplasm; nucleolus; nucleus
Molecular Function: metal ion binding; calcium ion binding
Biological Process: activation of store-operated calcium channel activity; transport; immune system process; calcium ion transport; ion transport; positive regulation of calcium ion transport
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Product Notes
The Mouse EFCAB4B efcab4b (Catalog #AAA9324953) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9324953 ELISA Kit recognizes Mouse EFCAB4B. It is sometimes possible for the material contained within the vial of "EF-hand calcium binding domain 4B, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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