Rat ring finger protein 135 ELISA Kit | RNF135 elisa kit
Rat E3 ubiquitin-protein ligase RNF135, RNF135 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
RNF135: Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production. Defects in RNF135 are the cause of macrocephaly macrosomia facial dysmorphism syndrome (MMFD). MMFD is an autosomal dominant disorder characterized by the association of macrothrombocytopathy and progressive sensorineural hearing loss without renal dysfunction. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin ligase; EC 6.3.2.-; Calcium-binding; DNA replication; Ubiquitin conjugating system; Ligase
Cellular Component: cytoplasm
Molecular Function: ribonucleoprotein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity
Biological Process: positive regulation of interferon-beta production; innate immune response; protein ubiquitination; regulation of innate immune response
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Product Notes
The Rat RNF135 rnf135 (Catalog #AAA9324896) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9324896 ELISA Kit recognizes Rat RNF135. It is sometimes possible for the material contained within the vial of "ring finger protein 135, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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