Human integrin, alpha X (complement component 3 receptor 4 subunit) ELISA Kit | ITGAX elisa kit
Human Integrin alpha-X, ITGAX ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Uniprot Description
ITGAX: Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. Belongs to the integrin alpha chain family.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: cell surface; membrane; plasma membrane; integrin complex
Molecular Function: protein binding; metal ion binding; receptor activity
Biological Process: integrin-mediated signaling pathway; heterotypic cell-cell adhesion; organ morphogenesis; extracellular matrix organization and biogenesis; blood coagulation; cell adhesion; leukocyte migration
Disease: Systemic Lupus Erythematosus
Research Articles on ITGAX
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Product Notes
The Human ITGAX itgax (Catalog #AAA9324714) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9324714 ELISA Kit recognizes Human ITGAX. It is sometimes possible for the material contained within the vial of "integrin, alpha X (complement component 3 receptor 4 subunit), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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