Human protein phosphatase 1, regulatory (inhibitor) subunit 3B ELISA Kit | PPP1R3B elisa kit
Human Protein phosphatase 1 regulatory subunit 3B, PPP1R3B ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Jan 2011]
Uniprot Description
PPP1R3B: Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes.
Protein type: Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 8p23.1
Cellular Component: intracellular membrane-bound organelle; glycogen granule; protein phosphatase type 1 complex
Molecular Function: enzyme binding; protein phosphatase regulator activity; phosphoprotein phosphatase activity
Biological Process: glycogen metabolic process; regulation of glycogen catabolic process; dephosphorylation; regulation of catalytic activity; regulation of glycogen biosynthetic process
Research Articles on PPP1R3B
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Product Notes
The Human PPP1R3B ppp1r3b (Catalog #AAA9324146) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9324146 ELISA Kit recognizes Human PPP1R3B. It is sometimes possible for the material contained within the vial of "protein phosphatase 1, regulatory (inhibitor) subunit 3B, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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