Human GDNF family receptor alpha 1 ELISA Kit | GFRA1 elisa kit
Human GDNF family receptor alpha-1, GFRA1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Feb 2009]
Uniprot Description
GFRA1: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, GPI anchor; Receptor, misc.
Chromosomal Location of Human Ortholog: 10q26.11
Cellular Component: extrinsic to membrane; plasma membrane
Molecular Function: glial cell line-derived neurotrophic factor receptor activity; receptor binding
Biological Process: axon guidance; cell surface receptor linked signal transduction
Research Articles on GFRA1
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Product Notes
The Human GFRA1 gfra1 (Catalog #AAA9321396) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9321396 ELISA Kit recognizes Human GFRA1. It is sometimes possible for the material contained within the vial of "GDNF family receptor alpha 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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