Human GRB2-related adaptor protein 2 ELISA Kit | GRAP2 elisa kit
Human GRB2-related adapter protein 2, GRAP2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Uniprot Description
GADS: Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc. Belongs to the GRB2/sem-5/DRK family.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 22q13.2
Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol; endosome
Molecular Function: protein binding; SH3/SH2 adaptor activity
Biological Process: positive regulation of signal transduction; cell-cell signaling; Ras protein signal transduction; T cell costimulation; innate immune response; T cell receptor signaling pathway
Research Articles on GRAP2
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Product Notes
The Human GRAP2 grap2 (Catalog #AAA9321160) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9321160 ELISA Kit recognizes Human GRAP2. It is sometimes possible for the material contained within the vial of "GRB2-related adaptor protein 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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