Mouse tripartite motif-containing 32 ELISA Kit | TRIM32 elisa kit
Mouse E3 ubiquitin-protein ligase TRIM32, TRIM32 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
TRIM32: Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo. Defects in TRIM32 are the cause of limb-girdle muscular dystrophy type 2H (LGMD2H); also known as muscular dystrophy Hutterite type. LGMD2H is an autosomal recessive degenerative myopathy characterized by pelvic girdle, shoulder girdle and quadriceps muscle weakness. Clinical phenotype and severity are highly variable. Disease progression is slow and most patients remain ambulatory into the sixth decade of life. Defects in TRIM32 are the cause of Bardet-Biedl syndrome type 11 (BBS11). Bardet-Biedl syndrome (BBS) is a genetically heterogeneous, autosomal recessive disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. A relatively high incidence of BBS is found in the mixed Arab populations of Kuwait and in Bedouin tribes throughout the Middle East, most likely due to the high rate of consaguinity in these populations and a founder effect. Belongs to the TRIM/RBCC family.
Protein type: EC 6.3.2.19; Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.-; Ligase
Cellular Component: striated muscle thick filament; cytoplasm; intracellular; nucleus
Molecular Function: ubiquitin binding; myosin binding; protein self-association; zinc ion binding; coenzyme F420-2 alpha-glutamyl ligase activity; RNA binding; metal ion binding; ubiquitin-protein ligase activity; ribosomal S6-glutamic acid ligase activity; protein binding; translation initiation factor binding; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity; coenzyme F420-0 gamma-glutamyl ligase activity; ligase activity
Biological Process: positive regulation of neurogenesis; protein polyubiquitination; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of proteolysis; protein ubiquitination during ubiquitin-dependent protein catabolic process; positive regulation of cell cycle; protein ubiquitination; indirect flight muscle actin ubiquitination; positive regulation of cell growth; activation of NF-kappaB transcription factor; negative regulation of viral transcription; positive regulation of protein catabolic process; tissue homeostasis; innate immune response; positive regulation of transcription factor activity; positive regulation of neuron differentiation; positive regulation of cell migration; response to UV
Research Articles on TRIM32
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Product Notes
The Mouse TRIM32 trim32 (Catalog #AAA9320480) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9320480 ELISA Kit recognizes Mouse TRIM32. It is sometimes possible for the material contained within the vial of "tripartite motif-containing 32, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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