Mouse ATP-binding cassette, sub-family C (CFTR/MRP) , member 5 ELISA Kit | ABCC5 elisa kit
Mouse Multidrug resistance-associated protein 5, ABCC5 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The human protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that the human protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
ABCC5: Acts as a multispecific organic anion pump which can transport nucleotide analogs. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter, ABC family; Transporter
Cellular Component: membrane; perinuclear region of cytoplasm; integral to membrane
Molecular Function: ATPase activity, coupled to transmembrane movement of substances; organic anion transmembrane transporter activity; ATPase activity; nucleotide binding; ATP binding
Biological Process: transport; transmembrane transport; organic anion transport
Research Articles on ABCC5
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Product Notes
The Mouse ABCC5 abcc5 (Catalog #AAA9319868) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9319868 ELISA Kit recognizes Mouse ABCC5. It is sometimes possible for the material contained within the vial of "ATP-binding cassette, sub-family C (CFTR/MRP) , member 5, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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