Human optic atrophy 1 (autosomal dominant) ELISA Kit | OPA1 elisa kit

Human Dynamin-like 120 kDa protein, mitochondrial, OPA1 ELISA Kit

Cat. Num. AAA9319015

• Gene Names: OPA1; NPG; NTG; MGM1; largeG
• Reactivity: Human
• Synonyms: optic atrophy 1 (autosomal dominant); Human Dynamin-like 120 kDa protein; mitochondrial; OPA1 ELISA Kit; mitochondrial (OPA1) ELISA kit; FLJ12460; KIAA0567; MGM1; NPG; NTG; largeG; mitochondrial dynamin-like GTPase; optic atrophy 1; OPA1 elisa kit

• Reactivity: Human

• Assay Type: Quantitative Sandwich
• Detection Range: 0.5ng/ml-16ng/ml
• Sensitivity: 0.1ng/ml
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for OPA1 elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or test applications! This kit is intended to be used for determine the level of OPA1 (hereafter termed "analyte") in undiluted original Human serum, plasma or tissue homogenates samples. For other sample types please contact tech support to determine compatibility with this assay. This kit is not suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 224831243
• NCBI GeneID: 4976
• NCBI Accession #: NP_056375.2
• NCBI GenBank Nucleotide #: NM_015560.2
• UniProt Accession #: O60313; D3DNW4
• Molecular Weight: 111,631 Da
• NCBI Official Full Name: dynamin-like 120 kDa protein, mitochondrial isoform 1
• NCBI Official Synonym Full Names: optic atrophy 1 (autosomal dominant)
• NCBI Official Symbol: OPA1
• NCBI Official Synonym Symbols: NPG; NTG; MGM1; largeG
• NCBI Protein Information: dynamin-like 120 kDa protein, mitochondrial; optic atrophy protein 1; mitochondrial dynamin-like GTPase; dynamin-like guanosine triphosphatase
• UniProt Protein Name: Dynamin-like 120 kDa protein, mitochondrial
• Protein Family: Dynamin-like 120 kDa protein
• UniProt Gene Name: OPA1
• UniProt Synonym Gene Names: KIAA0567
• UniProt Entry Name: OPA1_HUMAN

NCBI Description

This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Uniprot Description

OPA1: a dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space. Defects in OPA1 are the cause of optic atrophy 1 and deafness. Eight splice-variant isoforms have been described.

Protein type: Apoptosis; Mitochondrial; EC 3.6.5.5; Membrane protein, integral; Hydrolase

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: nucleoplasm; mitochondrial outer membrane; mitochondrial crista; membrane; mitochondrion; dendrite; cytoplasm; mitochondrial inner membrane; integral to membrane; mitochondrial intermembrane space

Molecular Function: GTPase activity; protein binding; GTP binding; magnesium ion binding

Biological Process: inner mitochondrial membrane organization and biogenesis; mitochondrion organization and biogenesis; mitochondrial fission; mitochondrial genome maintenance; axon transport of mitochondrion; mitochondrial fusion; visual perception; metabolic process; apoptosis; neural tube closure

Disease: Glaucoma, Normal Tension, Susceptibility To; Optic Atrophy With Or Without Deafness, Ophthalmoplegia, Myopathy, Ataxia, And Neuropathy; Optic Atrophy 1