Mouse jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae) ELISA Kit | JHDM1D elisa kit
Mouse Lysine-specific demethylase 7, JHDM1D ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
JHDM1D: Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.14.11.-
Cellular Component: nucleoplasm; nucleolus; nucleus
Molecular Function: zinc ion binding; histone demethylase activity (H3-K36 specific); metal ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; oxidoreductase activity; histone demethylase activity (H3-K9 specific); methylated histone residue binding; procollagen-proline dioxygenase activity; 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity; dioxygenase activity; sulfonate dioxygenase activity; iron ion binding; DNA-N1-methyladenine dioxygenase activity
Biological Process: nervous system development; histone H3-K9 demethylation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; chromatin modification
Research Articles on JHDM1D
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Product Notes
The Mouse JHDM1D kdm7a (Catalog #AAA9317053) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9317053 ELISA Kit recognizes Mouse JHDM1D. It is sometimes possible for the material contained within the vial of "jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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