Mouse PR domain containing 1, with ZNF domain ELISA Kit | PRDM1 elisa kit

Mouse PR domain zinc finger protein 1, PRDM1 ELISA Kit

Cat. Num. AAA9316058

• Gene Names: Prdm1; Blimp1; Blimp-1; PRDI-BF1; ZNFPR1A1; b2b1765Clo
• Reactivity: Mouse
• Synonyms: PR domain containing 1; with ZNF domain; Mouse PR domain zinc finger protein 1; PRDM1 ELISA Kit; Mouse PR domain zinc finger protein 1 (PRDM1) ELISA kit; RP1-134E15.1; BLIMP1; MGC118922; MGC118923; MGC118924; MGC118925; PRDI-BF1; B-lymphocyte-induced maturation protein 1; PR-domain zinc finger protein 1; PRDI-binding factor-1; beta-interferon gene posit; PRDM1 elisa kit

• Reactivity: Mouse

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 172073164
• NCBI GeneID: 12142
• NCBI Accession #: NP_031574.2
• NCBI GenBank Nucleotide #: NM_007548.3
• UniProt Accession #: Q60636; Q3UET9; A2VDE8
• Molecular Weight: 95,836 Da
• NCBI Official Full Name: PR domain zinc finger protein 1
• NCBI Official Synonym Full Names: PR domain containing 1, with ZNF domain
• NCBI Official Symbol: Prdm1
• NCBI Official Synonym Symbols: Blimp1; Blimp-1; PRDI-BF1; ZNFPR1A1; b2b1765Clo
• NCBI Protein Information: PR domain zinc finger protein 1; PR domain-containing protein 1; PR domain containing 1 with ZNF domain; B lymphocyte induced maturation protein; B lymphocyte-induced maturation protein 1; beta-interferon gene positive regulatory domain I-binding factor
• UniProt Protein Name: PR domain zinc finger protein 1
• Protein Family: PR domain zinc finger protein
• UniProt Gene Name: Prdm1
• UniProt Synonym Gene Names: Blimp1; Blimp-1
• UniProt Entry Name: PRDM1_MOUSE

Uniprot Description

PRDM1: a transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene and can inhibit virus-mediated IFN-¿ production. Recruits chromatin-modifying enzymes including histone deacetylases and methyltransferases. Drives the maturation of B-lymphocytes into Ig secreting cells. Interacts with PRMT5. Expression of Blimp-1 is sufficient to drive terminal differentiation of BCL1 lymphoma cells into antibody secreting plasma cells, increasing the expression of the cell surface marker Syndecan-1. In the B-cell lineage, Blimp-1 is specifically expressed in antibody-secreting cells including activated B and plasma cells. In addition, Blimp-1 has been found during macrophage differentiation and in a subset of T-cells suggesting that it may play a wider role in homeostasis and differentiation. Target genes of Blimp-1 transcriptional repression with potential roles in differentiation include c-Myc, CIITA, Pax5, Spi-B, and Id3.Three isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; Transcription, coactivator/corepressor; DNA-binding; Methyltransferase, protein lysine, predicted; Transcription regulation

Cellular Component: cytoplasm; nucleus

Molecular Function: methyltransferase activity; trimethylamine methyltransferase activity; monomethylamine methyltransferase activity; histone deacetylase binding; RNA methyltransferase activity; tRNA (cytosine)-methyltransferase activity; rRNA (cytosine-C5-967)-methyltransferase activity; rRNA (uridine) methyltransferase activity; N-methyltransferase activity; transcription factor activity; tRNA (guanine) methyltransferase activity; rRNA (adenine-N6,N6-)-dimethyltransferase activity; arginine N-methyltransferase activity; selenocysteine methyltransferase activity; protein-arginine N-methyltransferase activity; methanol-specific methylcobalamin:coenzyme M methyltransferase activity; tRNA (guanine-N2-)-methyltransferase activity; dimethylamine methyltransferase activity; protein methyltransferase activity; 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity; hydroxyneurosporene-O-methyltransferase activity; transferase activity; rRNA (uridine-2'-O-)-methyltransferase activity; tRNA (uracil) methyltransferase activity; rRNA (adenine) methyltransferase activity; C-methyltransferase activity; cobalt-precorrin-6B C5-methyltransferase activity; cobalt-precorrin-3 C17-methyltransferase activity; 1-phenanthrol methyltransferase activity; metal ion binding; S-methyltransferase activity; lysine N-methyltransferase activity; DNA-methyltransferase activity; tRNA (cytosine-5-)-methyltransferase activity; tRNA (adenine)-methyltransferase activity; C-terminal protein carboxyl methyltransferase activity; nucleic acid binding; rRNA (cytosine) methyltransferase activity; sequence-specific DNA binding; cobalt-precorrin-7 C15-methyltransferase activity; protein-arginine N5-methyltransferase activity; rRNA methyltransferase activity; protein-leucine O-methyltransferase activity; demethylmenaquinone methyltransferase activity; rRNA (adenine-N6-)-methyltransferase activity; tRNA methyltransferase activity; rRNA (guanine) methyltransferase activity; methylarsonite methyltransferase activity; protein binding; mRNA methyltransferase activity; methylamine-specific methylcobalamin:coenzyme M methyltransferase activity; DNA binding; tRNA (guanine-N1-)-methyltransferase activity; cobalt-precorrin-5B C1-methyltransferase activity; protein-lysine N-methyltransferase activity; O-methyltransferase activity; tRNA (adenine-N1-)-methyltransferase activity; tRNA (adenine-57, 58-N(1)-) methyltransferase activity

Biological Process: transcription from RNA polymerase II promoter; methylation; negative regulation of lipopolysaccharide-mediated signaling pathway; embryonic placenta development; cellular developmental process; cell fate commitment; transcription, DNA-dependent; in utero embryonic development; multicellular organismal development; morphogenesis of a branching structure; negative regulation of B cell proliferation; negative regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; post-embryonic development; germ cell development; eye photoreceptor cell development; regulation of transcription, DNA-dependent; artery morphogenesis; positive regulation of B cell differentiation; maternal placenta development