Human Triadin (TRDN) ELISA Kit | TRDN elisa kit
Human Triadin (TRDN) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an integral membrane protein that contains a single transmembrane domain. As similar protein in rabbits plays a role in skeletal muscle excitation-contraction coupling as part of the calcium release complex in association with the ryanodine receptor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and single nucleotide polymorphisms in this gene may be markers for IgA nephritis. [provided by RefSeq, Oct 2011]
Uniprot Description
TRDN: May be involved in anchoring calsequestrin to the junctional sarcoplasmic reticulum and allowing its functional coupling with the ryanodine receptor. TRDN mutations have been found in catecholaminergic polymorphic ventricular tachycardia (CPVT) (PubMed:22422768). CPVT is an arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death.
Protein type: Endoplasmic reticulum; Membrane protein, integral
Chromosomal Location of Human Ortholog: 6q22.31
Cellular Component: sarcoplasmic reticulum membrane; sarcoplasmic reticulum lumen; sarcoplasmic reticulum; endoplasmic reticulum; cytoplasm; junctional membrane complex; plasma membrane; integral to membrane; voltage-gated calcium channel complex
Molecular Function: protein binding, bridging; protein binding; receptor binding
Biological Process: cellular calcium ion homeostasis; muscle contraction; heart contraction; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; transmembrane transport; regulation of release of sequestered calcium ion into cytosol; cytoplasmic microtubule organization and biogenesis
Disease: Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/or Dilated Cardiomyopathy; Ventricular Tachycardia, Catecholaminergic Polymorphic, 5, With Or Without Muscle Weakness
Research Articles on TRDN
Similar Products
Product Notes
The Human TRDN trdn (Catalog #AAA9313022) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9313022 ELISA Kit recognizes Human TRDN. It is sometimes possible for the material contained within the vial of "Triadin (TRDN), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
