Human Apoptosis Inhibitor 5 (API5) ELISA Kit | API5 elisa kit
Human Apoptosis Inhibitor 5 (API5) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Uniprot Description
API5: Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Belongs to the API5 family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA-binding; Apoptosis
Chromosomal Location of Human Ortholog: 11p11.2
Cellular Component: nucleoplasm; spliceosome; membrane; cytoplasm; nucleus
Molecular Function: protein binding; fibroblast growth factor binding
Biological Process: apoptosis; negative regulation of apoptosis
Research Articles on API5
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Product Notes
The Human API5 api5 (Catalog #AAA9311741) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9311741 ELISA Kit recognizes Human API5. It is sometimes possible for the material contained within the vial of "Apoptosis Inhibitor 5 (API5), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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