Guinea Pig nuclear receptor subfamily 1, group H, member 3 ELISA Kit | NR1H3 elisa kit
Guinea Pig Liver X Receptor alpha, LXRalpha ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
orphan receptor; involved in the stimulation of CYP7A1 transcription [RGD, Feb 2006]
Uniprot Description
LXR-alpha: Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Nuclear receptor; Motility/polarity/chemotaxis
Cellular Component: nuclear chromatin; cytoplasm; nucleus; receptor complex
Molecular Function: retinoid X receptor binding; ligand-dependent nuclear receptor activity; sterol response element binding; DNA binding; zinc ion binding; protein heterodimerization activity; sequence-specific DNA binding; steroid hormone receptor activity; transcription factor activity
Biological Process: negative regulation of lipid transport; transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of cellular protein metabolic process; lipid homeostasis; negative regulation of transcription from RNA polymerase II promoter; cellular lipid metabolic process; negative regulation of pinocytosis; positive regulation of cholesterol transport; regulation of transcription, DNA-dependent; negative regulation of macrophage activation; negative regulation of proteolysis; positive regulation of fatty acid biosynthetic process; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; positive regulation of toll-like receptor 4 signaling pathway; cholesterol homeostasis; negative regulation of inflammatory response; insulin receptor signaling pathway; positive regulation of lipoprotein lipase activity; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; lipid metabolic process; sterol homeostasis; response to progesterone stimulus; negative regulation of transcription, DNA-dependent; apoptotic cell clearance
Research Articles on NR1H3
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Product Notes
The Guinea Pig NR1H3 nr1h3 (Catalog #AAA9311013) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9311013 ELISA Kit recognizes Guinea Pig NR1H3. It is sometimes possible for the material contained within the vial of "nuclear receptor subfamily 1, group H, member 3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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